DNA的损坏与修复过程

DNA damage is an abnormal chemical structure in DNA which can cause changes in the structure of the genetic material and prevents the replication mechanism from functioning and performing properly.

DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day. Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes. Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it undergoes mitosis. As a consequence, the DNA repair process is constantly active as it responds to damage in the DNA structure. When normal repair processes fail, and when cellular apoptosis does not occur, irreparable DNA damage may occur, including double-strand breaks and DNA crosslinkages (interstrand crosslinks or ICLs). This can eventually lead to malignant tumors, or cancer as per the two hit hypothesis.

ATM/ATR: https://www.tsbiochem.com/target/ATM-ATR

DNA-PK: https://www.tsbiochem.com/target/DNA-PK

DNA: https://www.tsbiochem.com/target/DNA

DNA Alkylation； https://www.tsbiochem.com/target/DNA-Alkylation

DNA gyrase： https://www.tsbiochem.com/target/DNA-gyrase

DNA/RNA Synthesis： https://www.tsbiochem.com/target/DNA-RNA-Synthesis

MTH1; https://www.tsbiochem.com/target/MTH1

Nucleoside Antimetabolite/Analog: https://www.tsbiochem.com/target/Nucleoside-Antimetabolite-Analog

Telomerase: https://www.tsbiochem.com/target/Telomerase

Topoisomerase； https://www.tsbiochem.com/target/Topoisomerase

HDAC： https://www.tsbiochem.com/target/HDAC

PARP： https://www.tsbiochem.com/target/PARP

Sirtuin： https://www.tsbiochem.com/target/Sirtuin

DNA Alkylator/Crosslinker： https://www.tsbiochem.com/target/DNA%20Alkylator-Crosslinker

Deubiquitinase： https://www.tsbiochem.com/target/Deubiquitinase

BMI-1： https://www.tsbiochem.com/target/BMI-1

DHFR： https://www.tsbiochem.com/target/DHFR

PPAR： https://www.tsbiochem.com/target/PPAR